Health-related quality of life in the WA HIV Cohort: 2008

Quality of life (QOL) is an important outcome of HIV treatment and a priority in the management of HIV. A new Patient-Reported Outcomes (PRO) questionnaire to measure the QOL in people living with HIV/AIDS (PLWHA) from different cultures and language groups has been developed. The instrument, PROQOL-HIV, has undergone psychometric validation in 791 individuals from 8 countries including 99 people from the WA HIV Cohort Study

A Parameterization Scheme for Lossy Transmission Line Macromodels with Application to High Speed Interconnects in Mobile Devices

We introduce a novel parameterization scheme based on the generalized method of characteristics (MoC) formacromodels of transmission-line structures having a cross section depending on several free geometrical and material parameters. This situation is common in early design stages, when the physical structures still have to be finalized and optimized under signal integrity and electromagnetic compatibility constraints. The topology of the adopted line macromodels has been demonstrated to guarantee excellent accuracy and efficiency. The key factors are propagation delay extraction and rational approximations, which intrinsically lead to a SPICE-compatible macromodel stamp. We introduce a scheme that parameterizes this stamp as a function of geometrical and material parameters such as conductor-width and separation, dielectric thickness, and permettivity. The parameterization is performed via multidimensional interpolation of the residue matrices in the rational approximation of characteristic admittance and propagation operators. A significant advantage of this approach consists of the possibility of efficiently utilizing the MoC methodology in an optimization scheme and eventually helping the design of interconnects.We apply the proposed scheme to flexible printed interconnects that are typically found in portable devices having moving parts. Several validations demonstrate the effectiveness of the approac

Isolation and mapping of a C3'H gene (CYP98A49) from globe artichoke, and its expression upon UV-C stress

Globe artichoke represents a natural source of phenolic compounds with dicaffeoylquinic acids along with their biosynthetic precursor chlorogenic acid (5-caffeoylquinic acid) as the predominant molecules. We report the isolation and characterization of a full-length cDNA and promoter of a globe artichoke p-coumaroyl ester 3¿-hydroxylase (CYP98A49), which is involved in both chlorogenic acid and lignin biosynthesis. Phylogenetic analyses demonstrated that this gene belongs to the CYP98 family. CYP98A49 was also heterologously expressed in yeast, in order to perform an enzymatic assay with p-coumaroylshikimate and p-coumaroylquinate as substrates. Real Time quantitative PCR analysis revealed that CYP98A49 expression is induced upon exposure to UV-C radiation. A single nucleotide polymorphism in the CYP98A49 gene sequence of two globe artichoke varieties used for genetic mapping allowed the localization of this gene to linkage group 10 within the previously developed map

Identifying Organizational Stressors That Could Be a Source of Discomfort in Police Officers: A Thematic Review

The aim of this paper is to highlight the organizational factors that might influence perceived discomfort in police officers. The studies included in the thematic review referred to specific factors, not the general terms “organizational stressors” or “workplace stressors”. It is important to emphasize this distinction because most studies use the general term “organizational stressor” (referring to context) to distinguish from “operational stressor” (referring to content, such as exposure to danger, threat, and trauma). For our purposes, we selected the studies that examined specific organizational factors. The results indicate that organizational social support, organizational culture, leadership, and bureaucracy are the organizational factors associated with police officers’ perceived discomfort. These organizational factors could have negative impacts on individuals, perceptions of stigma when contacting support services, anxiety and depressive symptoms, burnout, PTSD, and suicidal thoughts, among others